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Vaksin ini tidak memerlukan pendinginan dan dapat dibekukan untuk transportasi. Namun, vaksin ini menghasilkan tanggapan kekebalan yang lebih lemah sehingga diperlukan suntikan tambahan untuk mempertahankan kekebalan. [ 12 ]Upaya awal ini telah menyebabkan kebanyakan vaksin yang tersedia saat ini. Meskipun upaya ini berhasil memberikan kekebalan, p
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